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- Platelet-rich plasma: a milieu of bioactive factors.Arthroscopy. 2012; 28: 429-439
- Platelet-rich plasma: from basic science to clinical applications.Am J Sports Med. 2009; 37: 2259-2272
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- Platelet-rich plasma differs according to preparation method and human variability.J Bone Joint Surg Am. 2012; 94: 308-316
- Growth factor and catabolic cytokine concentrations are influenced by the cellular composition of platelet-rich plasma.Am J Sports Med. 2011; 39: 2135-2140
- Temporal growth factor release from platelet-rich plasma, trehalose lyophilized platelets, and bone marrow aspirate and their effect on tendon and ligament gene expression.J Orthop Res. 2009; 27: 1033-1042
- Effect of high-volume injection, platelet-rich plasma, and sham treatment in chronic midportion Achilles tendinopathy: a randomized double-blinded prospective study.Am J Sports Med. 2017; 45: 2034-2043
- One-year follow-up of platelet-rich plasma treatment in chronic Achilles tendinopathy: a double-blind randomized placebo-controlled trial.Am J Sports Med. 2011; 39: 1623-1629
- Ultrasound-guided injection therapy of Achilles tendinopathy with platelet-rich plasma or saline: a randomized, blinded, placebo-controlled trial.Am J Sports Med. 2016; 44: 1990-1997
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- Platelet-rich plasma versus corticosteroid injection for recalcitrant lateral epicondylitis: clinical and ultrasonographic evaluation.J Orthop Surg. 2015; 23: 1-5
- Ongoing positive effect of platelet-rich plasma versus corticosteroid injection in lateral epicondylitis: a double-blind randomized controlled trial with 2-year follow-up.Am J Sports Med. 2011; 39: 1200-1208
- Treatment of lateral epicondylitis with platelet-rich plasma, glucocorticoid, or saline: a randomized, double-blind, placebo-controlled trial.Am J Sports Med. 2013; 41: 625-635
- A randomized study of autologous conditioned plasma and steroid injections in the treatment of lateral epicondylitis.Int Orthop. 2015; 39: 2199-2203
- Efficacy of platelet-rich plasma for chronic tennis elbow: a double-blind, prospective, multicenter, randomized controlled trial of 230 patients.Am J Sports Med. 2014; 42: 463-471
- Inefficacy of ultrasound-guided local injections of autologous conditioned plasma for recent epicondylitis: results of a double-blind placebo-controlled randomized clinical trial with one-year follow-up.Rheumatology. 2016; 55: 279-285
- Effects of platelet-rich plasma on lateral epicondylitis of the elbow: prospective randomized controlled trial.Rev Bras Ortop. 2016; 51: 90-95
- Do blood growth factors offer additional benefit in refractory lateral epicondylitis? A prospective, randomized pilot trial of dry needling as a stand-alone procedure versus dry needling and autologous conditioned plasma.Skeletal Radiol. 2013; 42: 1515-1520
- Comparison of local injection of platelet rich plasma and corticosteroids in the treatment of lateral epicondylitis of humerus.J Clin Diagn Res. 2015; 9: RC05-RC07
- Platelet-rich plasma as a treatment for patellar tendinopathy: a double-blind, randomized controlled trial.Am J Sports Med. 2014; 42: 610-618
- Platelet-rich plasma versus focused shock waves in the treatment of jumper’s knee in athletes.Am J Sports Med. 2013; 41: 795-803
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- The comparison of the effect of corticosteroids and platelet-rich plasma (PRP) for the treatment of plantar fasciitis.Arch Orthop Trauma Surg. 2012; 132: 781-785
- Platelet rich plasma versus corticosteroid injection for plantar fasciitis: a comparative study.Foot. 2015; 25: 235-237
- Comparison of plantar fasciitis injected with platelet-rich plasma vs corticosteroids.Foot Ankle Int. 2018; 39: 780-786
- Chronic plantar fasciitis: effect of platelet-rich plasma, corticosteroid, and placebo.Orthopedics. 2016; 39: e285-e289
- Platelet-rich plasma efficacy versus corticosteroid injection treatment for chronic severe plantar fasciitis.Foot Ankle Int. 2014; 35: 313-318
- Local injection of autologous platelet rich plasma and corticosteroid in treatment of lateral epicondylitis and plantar fasciitis: randomized clinical trial.Egypt Rheumatol. 2012; 34: 43-49
- Comparison of platelet-rich plasma and steroid injection in the treatment of plantar fasciitis.Acta Orthop Traumatol Turc. 2014; 48: 667-672
- Local injection of autologous platelet rich plasma compared to corticosteroid treatment of chronic plantar fasciitis patients: a clinical and ultrasonographic follow-up study.Egypt Rheumatol. 2016; 38: 247-252
- A study to compare the efficacy of corticosteroid therapy with platelet-rich plasma therapy in recalcitrant plantar fasciitis: a preliminary report.Foot Ankle Surg. 2014; 20: 10-13
- Platelet rich plasma therapy: a comparative effective therapy with promising results in plantar fasciitis.J Clin Orthop Trauma. 2013; 4: 31-35
- Beneficial effects of platelet-rich plasma on improvement of pain severity and physical disability in patients with plantar fasciitis: a randomized trial.Adv Biomed Res. 2016; 5: 179
- Platelet-rich plasma injections in the treatment of chronic rotator cuff tendinopathy: a randomized controlled trial with 1-year follow-up.Am J Sports Med. 2013; 41: 2609-2616
- Comparison of the therapeutic effects of ultrasound-guided platelet-rich plasma injection and dry needling in rotator cuff disease: a randomized controlled trial.Clin Rehabil. 2013; 27: 113-122
- Subacromial injection of autologous platelet-rich plasma versus corticosteroid for the treatment of symptomatic partial rotator cuff tears.Eur J Orthop Surg Traumatol. 2016; 26: 837-842
- Efficacy of platelet-rich plasma injections for symptomatic tendinopathy: systematic review and meta-analysis of randomised injection-controlled trials.BMJ Open Sport Exerc Med. 2017; 3: e000237
- Positive effect of an autologous platelet concentrate in lateral epicondylitis in a double-blind randomized controlled trial: platelet-rich plasma versus corticosteroid injection with a 1-year follow-up.Am J Sports Med. 2010; 38: 255-262
- Platelet-rich plasma versus autologous blood versus steroid injection in lateral epicondylitis: systematic review and network meta-analysis.J Orthop Traumatol. 2016; 17: 101-112
- Comparative effectiveness of injection therapies in lateral epicondylitis: a systematic review and network meta-analysis of randomized controlled trials.Am J Sports Med. 2013; 41: 1435-1446
- Platelet-rich plasma injection for chronic Achilles tendinopathy: a randomized controlled trial.JAMA. 2010; 303: 144-149
- No effects of PRP on ultrasonographic tendon structure and neovascularisation in chronic midportion Achilles tendinopathy.Br J Sports Med. 2011; 45: 387-392
- Plantar fasciitis: evaluation and treatment.J Am Acad Orthop Surg. 2008; 16: 338-346
- Platelet-rich plasma as a treatment for plantar fasciitis: a meta-analysis of randomized controlled trials.Medicine (Baltimore). 2017; 96: e8475
- A systematic review and meta-analysis of platelet-rich plasma versus corticosteroid injections for plantar fasciopathy.Int Orthop. 2017; 41: 1169-1181
- Basic science of articular cartilage and osteoarthritis.Clin Sports Med. 2005; 24: 1-12
- Biochemical investigation of the effects of human platelet releasates on human articular chondrocytes.J Cell Biochem. 2009; 108: 1153-1165
- The regenerative effect of platelet-rich plasma on healing in large osteochondral defects.Int Orthop. 2010; 34: 589-597
- Platelet-rich plasma in the pathologic processes of cartilage: review of basic science evidence.Arthroscopy. 2013; 29: 1399-1409
- Efficacy of ultrasound-guided intra-articular injections of platelet-rich plasma versus hyaluronic acid for hip osteoarthritis.Orthopedics. 2013; 36: e1501-e1508
- Ultrasound-guided injection of platelet-rich plasma and hyaluronic acid, separately and in combination, for hip osteoarthritis: a randomized controlled study.Am J Sports Med. 2016; 44: 664-671
- Treatment of early hip osteoarthritis: ultrasound-guided platelet rich plasma versus hyaluronic acid injections in a randomized clinical trial.Joints. 2017; 5: 152-155
- Intra-articular hyaluronic acid vs platelet-rich plasma in the treatment of hip osteoarthritis.Med Ultrason. 2016; 18: 463-468
- Comparison between hyaluronic acid and platelet-rich plasma, intra-articular infiltration in the treatment of gonarthrosis.Am J Sports Med. 2012; 40: 2822-2827
- Hyaluronic acid versus platelet-rich plasma: a prospective, double-blind randomized controlled trial comparing clinical outcomes and effects on intra-articular biology for the treatment of knee osteoarthritis.Am J Sports Med. 2017; 45: 339-346
- Choice of intra-articular injection in treatment of knee osteoarthritis: platelet-rich plasma, hyaluronic acid or ozone options.Knee Surg Sports Traumatol Arthrosc. 2017; 25: 485-492
- Platelet-rich plasma intra-articular knee injections show no superiority versus viscosupplementation: a randomized controlled trial.Am J Sports Med. 2015; 43: 1575-1582
- Platelet-rich plasma vs hyaluronic acid to treat knee degenerative pathology: study design and preliminary results of a randomized controlled trial.BMC Musculoskelet Disord. 2012; 13: 229
- Multiple PRP injections are more effective than single injections and hyaluronic acid in knees with early osteoarthritis: a randomized, double-blind, placebo-controlled trial.Knee Surg Sports Traumatol Arthrosc. 2017; 25: 958-965
- Randomized controlled trial comparing hyaluronic acid, platelet-rich plasma and the combination of both in the treatment of mild and moderate osteoarthritis of the knee.J Stem Cells Regen Med. 2016; 12: 69-78
- Intra-articular injections of platelet-rich plasma versus hyaluronic acid in the treatment of osteoarthritic knee pain: a randomized clinical trial in the context of the Spanish National Health Care System.Int J Mol Sci. 2016; 17 ([pii:E1064])
- Treatment with platelet-rich plasma is more effective than placebo for knee osteoarthritis: a prospective, double-blind, randomized trial.Am J Sports Med. 2013; 41: 356-364
- Intra-articular injection of photo-activated platelet-rich plasma in patients with knee osteoarthritis: a double-blind, randomized controlled pilot study.BMC Musculoskelet Disord. 2016; 17: 67
- Knee osteoarthritis injection choices: Platelet-Rich Plasma (PRP) versus hyaluronic acid (a one-year randomized clinical trial).Clin Med Insights Arthritis Musculoskelet Disord. 2015; 8: 1-8
- Does intra articular platelet rich plasma injection improve function, pain and quality of life in patients with osteoarthritis of the knee? A randomized clinical trial.Orthop Rev. 2014; 6: 5405
- A randomized clinical trial evaluating plasma rich in growth factors (PRGF-Endoret) versus hyaluronic acid in the short-term treatment of symptomatic knee osteoarthritis.Arthroscopy. 2012; 28: 1070-1078
- Leukocyte-poor platelet-rich plasma is more effective than the conventional therapy with acetaminophen for the treatment of early knee osteoarthritis.Arch Orthop Trauma Surg. 2016; 136: 1723-1732
- Intra-articular autologous conditioned plasma injections provide safe and efficacious treatment for knee osteoarthritis: an FDA-sanctioned, randomized, double-blind, placebo-controlled clinical trial.Am J Sports Med. 2016; 44: 884-891
- Comparison of intra-articular injections of Plasma Rich in Growth Factors (PRGF-Endoret) versus durolane hyaluronic acid in the treatment of patients with symptomatic osteoarthritis: a randomized controlled trial.Arthroscopy. 2013; 29: 1635-1643
- The temporal effect of platelet-rich plasma on pain and physical function in the treatment of knee osteoarthritis: systematic review and meta-analysis of randomized controlled trials.J Orthop Surg. 2017; 12: 16
- Effect of leukocyte concentration on the efficacy of platelet-rich plasma in the treatment of knee osteoarthritis.Am J Sports Med. 2016; 44: 792-800
- Platelet-rich plasma in patients with tibiofemoral cartilage degeneration.Arch Orthop Trauma Surg. 2013; 133: 1295-1301
- Growth factors in the treatment of early osteoarthritis.Clin Cases Miner Bone Metab. 2013; 10: 26-29
- Basic science of articular cartilage.Clin Sports Med. 2017; 36: 413-425
- The effect of platelet-rich plasma formulations and blood products on human synoviocytes: implications for intra-articular injury and therapy.Am J Sports Med. 2014; 42: 1204-1210
- Effects of platelet-rich fibrin matrix on repair integrity of at-risk rotator cuff tears.Am J Sports Med. 2012; 40: 286-293
- Platelet-rich plasma augmentation for arthroscopic rotator cuff repair: a randomized controlled trial.Am J Sports Med. 2011; 39: 258-265
- Platelet-rich plasma supplementation in arthroscopic repair of full-thickness rotator cuff tears: a randomized clinical trial.Musculoskelet Surg. 2016; 100: 25-32
- A midterm evaluation of postoperative platelet-rich plasma injections on arthroscopic supraspinatus repair: a randomized controlled trial.Am J Sports Med. 2017; 45: 2965-2974
- Use of platelet-leukocyte membrane in arthroscopic repair of large rotator cuff tears: a prospective randomized study.J Bone Joint Surg Am. 2012; 94: 1345-1352
- Impact of platelet-rich plasma on arthroscopic repair of small- to medium-sized rotator cuff tears: a randomized controlled trial.Orthop J Sports Med. 2016; 4 (232596711666559)
- Platelet-rich plasma for arthroscopic repair of medium to large rotator cuff tears: a randomized controlled trial.Am J Sports Med. 2015; 43: 2102-2110
- Platelet-rich plasma in rotator cuff repair: a prospective randomized study.Am J Sports Med. 2014; 42: 2446-2454
- Platelet rich plasma in arthroscopic rotator cuff repair: a prospective RCT study, 2-year follow-up.J Shoulder Elbow Surg. 2011; 20: 518-528
- The effect of platelet-rich fibrin matrix on rotator cuff tendon healing: a prospective, randomized clinical study.Am J Sports Med. 2012; 40: 1234-1241
- Platelet-rich fibrin matrix in the management of arthroscopic repair of the rotator cuff: a prospective, randomized, double-blinded study.Am J Sports Med. 2013; 41: 263-270
- SECEC Research Grant 2008 II: Use of platelet- and leucocyte-rich fibrin (L-PRF) does not affect late rotator cuff tendon healing: a prospective randomized controlled study.J Shoulder Elbow Surg. 2016; 25: 2-11
- Triple-loaded single-row versus suture-bridge double-row rotator cuff tendon repair with platelet-rich plasma fibrin membrane: a randomized controlled trial.Arthroscopy. 2016; 32: 753-761
- Does application of moderately concentrated platelet-rich plasma improve clinical and structural outcome after arthroscopic repair of medium-sized to large rotator cuff tear? A randomized controlled trial.J Shoulder Elbow Surg. 2016; 25: 1312-1322
- Does pure platelet-rich plasma affect postoperative clinical outcomes after arthroscopic rotator cuff repair? A randomized controlled trial.Am J Sports Med. 2016; 44: 2136-2146
- Efficacy of platelet-rich plasma in arthroscopic repair of full-thickness rotator cuff tears: a meta-analysis.J Shoulder Elbow Surg. 2015; 24: 1852-1859
- Does the use of platelet-rich plasma at the time of surgery improve clinical outcomes in arthroscopic rotator cuff repair when compared with control cohorts? A systematic review of meta-analyses.Arthroscopy. 2016; 32: 906-918
- Platelet-rich plasma in tendon-related disorders: results and indications.Knee Surg Sports Traumatol Arthrosc. 2018; 26: 1984-1999
- Platelet-rich plasma reduces retear rates after arthroscopic repair of small- and medium-sized rotator cuff tears but is not cost-effective.Am J Sports Med. 2015; 43: 3071-3076
Smith KM, Le A, Costouros J, et al. Biologics for rotator cuff repair: a critical analysis review. JBJS Rev, in press.
- Evaluation of low-level laser therapy, platelet-rich plasma, and their combination on the healing of Achilles tendon in rabbits.Lasers Med Sci. 2015; 30: 1305-1313
- Synergy of tendon stem cells and platelet-rich plasma in tendon healing.J Orthop Res. 2012; 30: 991-997
- Effects of platelet-rich plasma (PRP) on the healing of Achilles tendons of rats.Wound Repair Regen. 2012; 20: 748-756
- The effect of platelet rich plasma from bone marrow aspirate with added bone morphogenetic protein-2 on the Achilles tendon-bone junction in rabbits.Clin Orthop Surg. 2011; 3: 325-331
- Does a single application of PRP alter the expression of IGF-I in the early phase of tendon healing?.J Foot Ankle Surg. 2011; 50: 276-282
- Temporal and spatial expression of TGF-beta1 in an Achilles tendon section model after application of platelet-rich plasma.Foot Ankle Surg. 2010; 16: 137-141
- Comparison of the early period effects of bone marrow-derived mesenchymal stem cells and platelet-rich plasma on the Achilles tendon ruptures in rats.Connect Tissue Res. 2016; 57: 360-373
- The role of platelets in the treatment of Achilles tendon injuries.J Orthop Res. 2013; 31: 111-118
- Platelet concentrates and Achilles tendon healing.J Orthop Res. 2013; 31: 1500
- Low-level mechanical stimulation is sufficient to improve tendon healing in rats.J Appl Physiol 1985. 2012; 113: 1398-1402
- How can one platelet injection after tendon injury lead to a stronger tendon after 4 weeks? Interplay between early regeneration and mechanical stimulation.Acta Orthop. 2006; 77: 806-812
- Autologous platelets have no effect on the healing of human Achilles tendon ruptures: a randomized single-blind study.Am J Sports Med. 2011; 39: 38-47
- Can platelet-rich plasma have a role in Achilles tendon surgical repair?.Knee Surg Sports Traumatol Arthrosc. 2016; 24: 2231-2237
- A prospective study of platelet-rich plasma as biological augmentation for acute Achilles tendon rupture repair.Biomed Res Int. 2016; 2016: 1-8
- Biologic agents for anterior cruciate ligament healing: a systematic review.World J Orthop. 2016; 7: 592-603
- Effects of platelet concentrate and a bone plug on the healing of hamstring tendons in a bone tunnel.Arthroscopy. 2008; 24: 1373-1380
- Comparison of magnetic resonance imaging findings in anterior cruciate ligament grafts with and without autologous platelet-derived growth factors.Arthroscopy. 2010; 26: 50-57
- Magnetic resonance imaging evaluation of patellar tendon graft remodelling after anterior cruciate ligament reconstruction with or without platelet-rich plasma.J Orthop Surg (Hong Kong). 2013; 21: 10-14
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- Has platelet-rich plasma any role in anterior cruciate ligament allograft healing?.Arthroscopy. 2009; 25: 1206-1213
- Effects of a platelet gel on early graft revascularization after anterior cruciate ligament reconstruction: a prospective, randomized, double-blind, clinical trial.Eur Surg Res. 2010; 45: 77-85
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- Platelet-rich plasma promotes the proliferation of human muscle derived progenitor cells and maintains their stemness.PLoS One. 2013; 8: e64923
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Article info
Footnotes
Disclosure Statement: None (A.D.K. Le, L. Enweze, M.R. DeBaun). J.L. Dragoo – per the American Academy of Orthopaedic Surgeons Web site.